Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti- tumour necrosis factor-alpha (cA2) therapy
نویسندگان
چکیده
منابع مشابه
British Journal of Rheumatology 1997;36:643–650 REDUCTION OF SERUM MATRIX METALLOPROTEINASE 1 AND MATRIX METALLOPROTEINASE 3 IN RHEUMATOID ARTHRITIS PATIENTS FOLLOWING ANTI-TUMOUR NECROSIS FACTOR-a (cA2) THERAPY
Matrix metalloproteinase (MMP)-1 and MMP-3 levels were measured in serum samples from rheumatoid arthritis (RA) patients undergoing a double-blinded placebo-controlled trial with the chimaeric anti-tumour necrosis factor (TNF)-a antibody cA2. Both MMP-1 (PQ 0.015), but to a larger extent MMP-3 (PQ 0.001) levels were elevated in all RA patients prior to the commencement of the trial compared wit...
متن کاملIgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes.
BACKGROUND IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whet...
متن کاملEffect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain
Objective(s): Prevention of inflammation in early stages will be useful in maintaining vitality of the organism. The objective of this study was to evaluate the effects of doxycycline (DOX) or meloxicam (MLX) monotherapy and combination therapy on the levels of inflammatory mediators in the brain tissues of rats with Escherichia coli lipopolysaccharide (LPS)-induced br...
متن کاملSerum matrix metalloproteinase 3 in early rheumatoid arthritis is correlated with disease activity and radiological progression.
OBJECTIVE To analyze the clinical significance of serial measurements of serum matrix metalloproteinase 3 (MMP-3) levels in relation to markers of disease activity and radiological progression in early rheumatoid arthritis (RA). METHODS In a 3 year prospective study of 33 patients with early RA (symptoms < 1 year at entry) monthly measurements of serum MMP-3 were transformed into time integra...
متن کاملSerum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis
OBJECTIVE To explore the correlation between matrix metalloproteinase- (MMP-) 3 and histological synovitis in rheumatoid arthritis (RA). METHODS Serum MMP-3 of 62 patients with active RA was detected by ELISA. Serial synovial tissue sections from all RA patients, 13 osteoarthritis, and 10 orthopedic arthropathies patients were stained with hematoxylin and eosin and immunohistochemically for M...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Rheumatology
سال: 1997
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/36.6.643